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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SF3B1
All Species:
36.06
Human Site:
Y474
Identified Species:
66.11
UniProt:
O75533
Number Species:
12
Phosphosite Substitution
Charge Score:
0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
O75533
NP_036565.2
1304
145830
Y474
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Chimpanzee
Pan troglodytes
XP_516006
1379
153963
Y549
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Rhesus Macaque
Macaca mulatta
XP_001086317
1397
156322
Y567
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Dog
Lupus familis
XP_857149
1312
146628
Y482
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Cat
Felis silvestris
Mouse
Mus musculus
Q99NB9
1304
145798
Y474
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_421912
1383
154834
Y553
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Frog
Xenopus laevis
O57683
1307
146196
Y477
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
D
Zebra Danio
Brachydanio rerio
XP_684311
1315
147162
Y485
L
K
P
D
D
I
Q
Y
F
D
K
L
L
V
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
XP_623732
1315
147662
Y485
M
K
P
E
D
A
Q
Y
F
D
K
L
L
V
D
Nematode Worm
Caenorhab. elegans
NP_497853
1322
147305
E481
D
T
Q
P
K
N
A
E
L
P
P
L
K
P
D
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002323970
1267
141858
L441
Y
Q
Y
F
G
A
L
L
N
E
E
D
E
E
E
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_201232
1269
141432
G440
P
E
D
Y
Q
Y
F
G
S
L
L
N
E
E
N
Baker's Yeast
Sacchar. cerevisiae
P49955
971
110009
I243
T
K
P
Y
V
H
K
I
L
V
V
A
A
P
L
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
93.3
99.3
N.A.
99.9
N.A.
N.A.
N.A.
93.7
96.6
93.7
N.A.
N.A.
82.4
65.1
N.A.
Protein Similarity:
100
94.5
93.3
99.3
N.A.
100
N.A.
N.A.
N.A.
93.7
98.3
96.4
N.A.
N.A.
88.9
76.6
N.A.
P-Site Identity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
100
100
93.3
N.A.
N.A.
80
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
100
N.A.
N.A.
N.A.
100
100
100
N.A.
N.A.
93.3
13.3
N.A.
Percent
Protein Identity:
68.4
N.A.
N.A.
68.3
40.4
N.A.
Protein Similarity:
79.3
N.A.
N.A.
79.1
53.1
N.A.
P-Site Identity:
0
N.A.
N.A.
0
13.3
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
13.3
20
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
16
8
0
0
0
0
8
8
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
8
62
70
0
0
0
0
70
0
8
0
0
70
% D
% Glu:
0
8
0
8
0
0
0
8
0
8
8
0
16
16
16
% E
% Phe:
0
0
0
8
0
0
8
0
70
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
8
0
0
8
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
62
0
8
0
0
0
0
0
0
0
% I
% Lys:
0
77
0
0
8
0
8
0
0
0
70
0
8
0
0
% K
% Leu:
62
0
0
0
0
0
8
8
16
8
8
77
70
0
8
% L
% Met:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
0
8
0
0
8
0
0
8
% N
% Pro:
8
0
77
8
0
0
0
0
0
8
8
0
0
16
0
% P
% Gln:
0
8
8
0
8
0
70
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% S
% Thr:
8
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
8
0
0
0
0
8
8
0
0
70
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
8
16
0
8
0
70
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _